Why does the future of the deployment of the biannual injection of Lenacapavir for HIV depends on the uncertain financial support of PEPFAR?

** Lenacapavir: a promise to prevention in financial uncertainty **

The Global Fund initiative for HIV, tuberculosis and malaria marks a promising advance with the expected deployment of Lenacapavir, a biannual injection with impressive results in HIV prevention. For low -income countries like South Africa, this innovation signals a glimmer of hope, but its success will strongly depend on the financial support of the PEPFAR, whose future remains uncertain in the face of political changes. The prophylactic pre-exhibition represents a leap forward compared to traditional methods, but the fragility of funding exposes global health programs to critical risks.

Despite the financial challenges, Peter Sands
** Lenacapavir: a health revolution under the light of financial uncertainty **

The recent announcement of the Global Fund for HIV, tuberculosis and malaria marks a significant advance in the fight against HIV, in particular for low -income countries like South Africa. The promise to finance the deployment of the Biannual Lenacapavir injection, a promising preventive treatment, indicates a determination not to leave the political brakes and the financial uncertainties compromise health advances. However, behind this resolution, hovers the shadow of crucial support: that of Pepfar, the US government emergency aid budget.

### The real emergency of prevention

The prophylactic pre-exhibition (PREP) such as Lenacapavir represents a virtuous circle in the fight against HIV. With an efficiency estimated at almost 100%, this innovation could radically transform the prevention of the virus, in particular in areas where transmission by sexuality remains high. By way of comparison, existing prevention methods, often deployed in the context of daily oral treatments, come up against observance obstacles which harm their effectiveness. Lenacapavir, by changing the paradigms of preventive treatment, could not only reduce HIV infections, but also create a more accessible and attractive care model for risky communities.

### Financial environment: an approach storm

Pepfar’s financial support, announced in December, seemed promising, but with the recent changes in political orientation of the Trump administration, the future of this funding arouses concerns. The almost total cessation of funds for many aid programs is likely to affect millions of lives. Indeed, the fear of an American withdrawal could lead countries like South Africa to review their public health strategies, strongly depending on external funding for already fragile medical infrastructure.

### Economic interest at the heart of health

Peter Sands, the Executive Director of the Global Fund, evokes an argument that deserves to be more explored. In a globalized world, the acquisition of robust public health is just as crucial for global economic stability. The data from the Imperial College, London, report that a dollar invested in successful health interventions could bring up to $ 19. This return on investment is not limited to short -term savings in the health field; It extends to costs avoided linked to the loss of productivity, forced migrations and conflicts related to resources.

## towards a new philosophy of help

As observers of global health systems, it is essential to demand a reconfiguration of help models. Difficulty in political decision -making and fluctuations in financial commitments expose the fragility of global health programs. Cultural change towards an investment approach could encourage more savings to encourage healthy aid programs, thus facilitating an environment where health is not a simple cost, but capital.

### to a universal commitment

It is imperative that nations, including those that traditionally provide substantial aid, reaffirm their support in the face of these challenges. The Global Fund calls for a commitment of $ 18 billion for the coming period, an ambitious vision which, if it is realized, could avoid 400 million new infections and save 23 million lives by 2029. International solidarity, much more than a financial commitment, must result in a desire for political, ethical and social cooperation.

### Conclusion

As the world is facing multiple crises ranging from pandemics to economic issues, the way in which we approach these challenges as an international community is crucial. Lenacapavir may well, with good support and a solid financial strategy, become a turning point in the fight against HIV. While political uncertainty is settling in, the challenge is not only to fight a virus, but to re -imagine a resilient and sustainable global health framework. Now is the time to turn to reinforced global cooperation, embracing challenges with a renewed sense of emergency and commitment.

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